Autologous blood donation and directed donation are increasingly in demand. Some investigators concluded that autologous blood can be used safely only for the original donors, and others proposed that autologous donors present on greater risk
than
homologous donors in terms of their likelihood of transmitting a transfusion-related infection. There is controversy in the safety of directed donation.
We analyzed the frequency of infection markers (HBsAg, anti-HBc, anti-HIV, anti-HCV, ALT levels, and plasma reagin assay) in autologous donors (n=214) and directed donors (n=11.862). We compared the results with the data of voluntary donors at
Korean
Red Blood Center.
In autologous donors, the seropositive rates of HBsAg, anti-HBc, and anti-HCV were 5.1%, 45%, and 0%, respectively. The frequencies of the donors with elevated ALT and the donors with reactive RPR test were 2.9% and 0.9%, respectively.
In directed donors, the seropositive rates of HBsAg, and anti-HCV were 3.66% and 0.37%, respectively. The frequencies of the donors with elevated ALT and the donors with reactive RPR test were 1.85% and 0.23%, respectively.
In conclusion, there were no significant differences for infectious disease markers between voluntary blood donors and autologous blood donors, but there were sighificant differences between voluntary blood donors and directed donors in their low
positive rates for infectious markers.
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